[Are we controlling the sedation in ICU? A multicenter study results].

The aim of this study is to evaluate the issues of sedation and analgesia in all-purpose ICUs in Russia. To obtain that, a single-day observational survey was performed in 55 ICUs of Ural and Siberia regions. This work enabled to describe the targets, instruments of control and patterns of sedative and analgetics and sedatives prescription, as well as to make conclusions about issues in this area and possibilities of creation and necessity of analgesia and sedation standards.

[Disturbances of immune status and cytokine profile caused by chronic intoxication with organophosphorus compounds and their correction by administration of imunofan].

Experiments on noninbred rats showed that the chronic intoxication with organophosphorus compounds sarin and methylparathion (30 days; total dose, 0.9 LD50; single daily dose, 0.03 mg/kg,) significantly decreases the immune responses and reduces the concentrations of blood cytokines IFN-gamma, IL-2, IL-4, IL-6, and IL-10.

[Effect of cholinesterase reactivator carboxim on T-lymphocyte acetylcholinesterase activity and immune response under conditions of acute intoxication by organophosphorus compounds].

It has been established in experiments on non-inbred rats that the administration of cholinesterase reactivator carboxim in a single dose of 10 mg/kg signifucantly reduces the inactivation of acetylcholinesterase in T-lymphocytes caused by acute intoxication with organophosphorus compounds (sarin, metaphos) in a dose of 1.0 LD50. The drug administration leads to partial or almost complete recovery of the humoral and cellular immune responses.

[Changes of the tissues and of regional lymph nodes in rats with chronic inflammatory process treated with interleukin-2].

The structure of Wistar rat subcutaneous adipose tissue and axillary (regional) lymph nodes (LN) was studied by the methods of light microscopy after the subcutaneous implantation of the fragments of silicone mammary implant in the area of right scapula in animals treated with interleukin-2 (IL-2). Subcutaneous implantation of sterile silicone plates to rats was found to induce chronic granulomatous inflammatory process with the formation of connective tissue capsule. Implants placement to rats treated with IL-2 resulted in the formation of a thicker capsule with the signs of sclerosis, fibrosis and hyialinosis; all the capsular structures were heavily infiltrated with macrophages, which contained phagocytozed silicone fragments.