Ultrastructure of the endothelium of the drainage system of the eye.

The endothelium of the ocular drainage system (Schlemm's canal, collector tubules, and aqueous veins) in primary juvenile glaucoma undergoes degenerative dystrophic changes with compensatory hypertrophy and proliferation at the initial stages of the glaucomatous process and atrophy and desquamation at advanced and terminal stages. Progressive decrease in the pinocytous function of endotheliocytes, reduction of the protein-synthesizing and mitochondrial compartments of the cytoplasm, and formation of autophagosomes reflect the process of endotheliocyte degeneration in general.

Mesenchymal stem cells transplantation could be beneficial for treatment of experimental ischemic stroke in rats.

Cell therapy is prospective, modern attempt to ischemic stroke treatment. It has been being widely worked out recently. We suggest mesenchymal stem cells (MSC) as a cell therapy agent in the therapy of this disease.

[Mesenchymal stem cells transplantation influences upon dynamics of morphological changes in rat brain after stroke].

Study of dynamic morphological changes if the brain after ischemic stroke is an important phase of pre-clinical trial of mesenchymal stem cell (MSC) therapy for this widespread disease. Experoments were carried out in inbred Wistar-Kyoto rats. MSCs were isolated, expanded in culture and labeled with vital fluorescent dye PKH26.

Distribution of mesenchymal stem cells in the area of tissue inflammation after transplantation of the cell material via different routes.

In experiments on male Wistar-Kyoto rats we studied the distribution of mesenchymal stem cells in intact body and in the presence of a focus of acute tissue inflammation. In healthy animals mesenchymal stem cells were transplanted intravenously. In the second case we used various routes of transplantation of mesenchymal stem cells: intravenous, into tissue adjacent to the inflammation focus, and into intact lobe of the damaged organ (prostate gland).

[Mesenchymal stem cells-based therapy of brain ischemic stroke in rat].

Mesenchymal stem cells (MSCs)-based therapy is a promising modern attempt to improve the recovery after stroke. Experiments were carried out on inbred Wistar-Kyoto rats. MSCs were isolated, expanded in cultute and labeled with vital fluorescent dye PKH-26.