Influence of radical prostatectomy on miRNA dynamics in urine extracellular vesicles.

Purpose: Cancer statistics demonstrate leading growth of prostate cancer. As a rule, radical prostatectomy (RP) is a mandatory option in the treatment of localized prostate cancer (PCa). Over 30% of patients develop biochemical resistance after the surgery and over 30% of these patients experience prostate cancer recurrence and metastasis.

[Retrospective analysis of causes of enucleations after anti-glaucomatous surgery].

Proximate causes of intraocular pressure (IOP) decompensation accompanied with persistent pain syndrome were determined based on results of morphological examination of 59 eyes enucleated due to terminal previously operated glaucoma and medical history analysis. Excessive scarring, formation of solid hyalinized membrane in the site of filter pad, closure of anterior chamber angle with synechia as an outcome of chronic iridocyclitis and inappropriate surgical approach lead to increase in the resistance of the aqueous humor outflow and result in glaucoma decompensation causing complications that necessitate enucleation. The most common complications are the following: bacterial corneal ulcer with potential perforation and endophthalmitis, hemorrhagic choroidal detachment, vitreous hemorrhage, persistent pain syndrome and phthisis bulbi.

[Choroidal melanoma and maculopathy].

Distant macular changes were revealed in 21 of 28 patients with intraocular melanoma. In 13 eyes maculopathy was very distant from choroidal melanoma (CM), in 4 cases the tumor was located preequatorially and in 9 patients in the posterior fundus beyond the macular zone. In 8 patients bilateral AMD was found along with CM.