Publications by authors named "E V Shchetinin"
Abstract: Cardiovascular disease remains the leading cause of disease burden globally with far-reaching consequences including enormous socio-economic burden to healthcare and society at large. Cardiovascular health is decisive for reproductive function, healthy pregnancy and postpartum. During pregnancy, maternal cardiovascular system is exposed to highly increased haemodynamic stress that significantly impacts health status of the mother and offspring.
View Article and Find Full Text PDFThe search and development of new antibiotics is relevant due to widespread antibiotic resistance. One of the promising strategies is the de novo design of novel antimicrobial peptides. The amino acid sequences of 198 novel peptides were obtained using a generative long short-term memory recurrent neural network (LSTM RNN).
View Article and Find Full Text PDFThe absence of effective drugs for COVID-19 prevention and treatment requires the search for new candidates among approved medicines. Fundamental studies and clinical observations allow us to approach an understanding of the mechanisms of damage and protection from exposure to SARS-CoV-2, to identify possible points of application for pharmacological interventions. In this review we presented studies on the anti-inflammatory, antioxidant, and immunotropic properties of melatonin.
View Article and Find Full Text PDFArticle Synopsis
- * Out of 13,595 patients surveyed, 26.14% received antimicrobials, primarily third-generation cephalosporins, and compliance with hospital antibiotic guidelines varied over the three studies, ranging from 66.8% to 74.8%.
- * The study highlighted issues such as low documentation rates for treatment indications and stop dates, high rates of prolonged perioperative antibiotic use, and insufficient targeted therapy, suggesting a need for tailored antimicrobial stewardship programs in hospitals.
Unlabelled: The search for osteoinductive as well as osteoconductive materials has led to the novel idea of using titanium in bone augmentations of the alveolar crest. Due to its excellent biocompatibility and favorable osteogenic properties, highly porous TiO granules has been proposed as a promising material for non-resorbable synthetic bone grafts in the restoration of large bone defects, and for bone augmentation in dental applications.
Objectives: The aim of this study was to investigate the osteoconductive properties and biological performance of porous titanium granules used in osseous defects adjacent to the maxillary sinus in sheep.