SPOCK2 controls the proliferation and function of immature pancreatic β-cells through MMP2.

Human pluripotent stem cell-derived β-cells (SC-β-cells) represent an alternative cell source for transplantation in diabetic patients. Although mitogens could in theory be used to expand β-cells, adult β-cells very rarely replicate. In contrast, newly formed β-cells, including SC-β-cells, display higher proliferative capacity and distinct transcriptional and functional profiles.

Oxidative RNA Modifications as an Early Response of Soybean ( L.) Exposed to Copper and Lead.

Plant exposure to metals is associated with the accumulation of reactive oxygen species, which mediate the oxidation of various molecules including lipids, proteins, and nucleic acids. The aim of the present study is the evaluation of the impact of short-term Cu and Pb treatment on oxidative events in the roots of soybean seedlings, with special emphasis on RNA oxidation. The results show that an increase in total RNA oxidative modification, 8-hydroxyguanosine (8-OHG), constitutes a very early response to both applied metals, observed already within the first hour of treatment.

Mitogen Synergy: An Emerging Route to Boosting Human Beta Cell Proliferation.

Decreased number and function of beta cells are a key aspect of diabetes mellitus (diabetes), a disease that remains an onerous global health problem. Means of restoring beta cell mass are urgently being sought as a potential cure for diabetes. Several strategies, such as beta cell derivation via pluripotent stem cell differentiation or mature somatic cell transdifferentiation, have yielded promising results.

[MATRIX METALLOPROTEINASE 9 AND TISSUE INHIBITOR OF MATRIX METALLOPROTEINASES TYPE 1 SERUM CONCENTRATIONS AND GENETIC POLYMORPHISM IN SENILE AORTIC STENOSIS].

The study of the serum levels of matrix metalloproteinase 9 (MMP9) and tissue inhibitor of matrix metalloproteinases type 1 (TIMP1) was conducted involving 108 patients aged over 65, with calcinosis and/or calcific aortic valve (AV) stenosis. The purpose of the study was to identify the molecular and genetic markers responsible for the development of senile aortic stenosis. Besides, there was also typing of polymorphic loci of MMP9 gene A8202G (rs1169732) and TIMP1 gene C536T(rs11551797) performed.

[Significance of indicator microorganisms in the assessment of a microbial risk in the occurrence of epidemic hazard in drinking water use].

Summary. The paper provides comparative characteristics of water quality in the assessment of a risk for intestinal infections in drinking water use. It has shown that of the greatest predictive value is direct detection of potentially pathogenic microorganisms, as well as the integral indicator determined by glucose fermentation, such as glucose-positive coliform bacteria.