[The effect of local chemical sympathectomy of the rat uterus on its sensitivity to sex hormones].

Chemical sympathectomy of the rat uterus did not alter the main metabolic processes maintaining the uterus weight even though it changed its response to sex steroids. Sensitivity of endo- and myometrium to progesterone significantly decreased thus inducing a relative increase in the estradiol action.

[The effect of postnatal sympathectomy on the production and receptor binding of sex steroids in female rats during puberty].

The total chemical desympathization caused by injection of 6-hydroxydopamine in the first day of life increased the progesterone secretion, decreased the estradiol secretion and abolished translocation of estradiol receptors to the cell nuclei in the uterus of 1-2 days old rats, which correlated with the absence of uterus weight increase after exogenous estradiol injections. The peripheral desympathization caused by injection of neurotoxin to two weeks old rats induced only estradiol secretion decrease, but to the less extent than after total desympathization.

[The content of sex steroid receptors and the activity of marker enzymes of estrogenic action in the uterus of androgen-sterile rats].

In rats with preserved ovaries, both in normal and in neonatally androgenized, the activity of enzymes kreatinphosphokinase and peroxidase cannot serve as the marker of the estradiol effect upon the uterus. In ovariectomised animals, the dynamics of activity of these enzymes corresponds to uterotropic responses to estradiol. but not to the dynamics of hormone receptor complexes.

[The effect of aminostimil on the regulation of sexual function in rats].

The effect of aminostimil: a synthetic drug of the acylhydrazide group, was studied in white rats. Aminostimil decreased the uterus weight but did not interfere with estrogen positive action in ovariectomized (OVX) rats, although it increased the FSH level, abolished the inhibitory effect of estradiol on the FSH secretion and did not change the secretion of the LH. Aminostimil induced accumulation of GnRH in the preoptic area and median eminence area in intact female and male rats, LH concentration in the blood plasma but decreased.