Publications by authors named "E V Sambatur"
The study aimed to develop structured, expert-based clinical guidance on the prenatal and postnatal management of hemolytic disease of the fetus and newborn. A Delphi procedure was conducted among an international panel of experts in fetal medicine, neonatology, and hematology. Experts were selected based on their expertise, relevant publications, and affiliations.
View Article and Find Full Text PDFObjective: This study aimed to investigate the outcomes associated with the administration of maternal intravenous immunoglobulin in high-risk red blood cell-alloimmunized pregnancies.
Data Sources: Medline, Embase, and Cochrane Library were systematically searched until June 2023.
Study Eligibility Criteria: This review included studies reporting on pregnancies with severe red blood cell alloimmunization, defined as either a previous fetal or neonatal death or the need for intrauterine transfusion before 24 weeks of gestation in the previous pregnancy as a result of hemolytic disease of the fetus and newborn.
Diagnostic yield of exome sequencing in prenatal agenesis of corpus callosum: systematic review and meta-analysis.
Ultrasound Obstet Gynecol
March 2024
Objectives: To determine the incremental diagnostic yield of exome sequencing (ES) after negative chromosomal microarray analysis (CMA) in cases of prenatally diagnosed agenesis of the corpus callosum (ACC) and to identify the associated genes and variants.
Methods: A systematic search was performed to identify relevant studies published up until June 2022 using four databases: PubMed, SCOPUS, Web of Science and The Cochrane Library. Studies in English reporting on the diagnostic yield of ES following negative CMA in prenatally diagnosed partial or complete ACC were included.
Article Synopsis
- The study investigates how effective prenatal exome sequencing is in detecting genetic conditions in fetuses diagnosed with severe ventriculomegaly or hydrocephalus when previous chromosomal tests yielded negative results.
- Researchers conducted a systematic review of studies published until June 2022 and reached out to authors for additional data, ultimately analyzing 28 studies with nearly 2,000 prenatal exome sequencing cases.
- The results highlighted the diagnostic potential of exome sequencing in identifying genetic variants, particularly in different categories of severe ventriculomegaly, although the specific yields varied based on the presence of other anomalies.