[Thickness of the retinal photoreceptor layers and the choroid, and bioelectrical activity of the macula in retinitis pigmentosa].

Purpose: To assess the changes in photoreceptor retinal layers and the choroid in comparison with bioelectrical activity of the macula in patients with retinitis pigmentosa (RP).

Material And Methods: The study included 10 patients (20 phakic eyes) with RP. Mean age was 27±18.

Stargardt disease-associated mutation spectrum of a Russian Federation cohort.

ABCA4-associated mutation screening is extensively performed in European, African, American and several other populations for various retinopathies. However, it has not been well studied in a Russian cohort. Using next-generation (325 genes inherited disease panel) and Sanger sequencing technologies for the first time we documented the spectrum of genetic variations in a Russian retinopathy cohort of 51 patients from 10 ethnic groups.

[Ocular blood flow and retinal electrogenesis in retinitis pigmentosa].

Aim: to investigate correlations between changes in ocular hemodynamics revealed by color Doppler flow mapping (CDFM) and pulsed-wave (PW) Doppler imaging, one the one hand, and electrical activity of the retina, on the other, in patients with early, moderate, and severe retinitis pigmentosa (RP).

Material And Methods: A total of 20 patients (40 eyes) aged from 16 to 40 years (28.4 ± 8.

[Macular and multifocal electroretinography in the diagnosis of Stargardt's dystrophy].

Retinal bioelectrical activity was studied in Stargardt's dystrophy from the data of multifocal and macular electroretinography (M-ERG) and retinal morphometry was carried out. The group of 11 patients (22 eyes) with the central form of Stargardt's dystrophy showed reductions in the retinal density of a bioelectric response of a P1 component, the amplitude of N1 and P1 components in the area of 0 to 16 degrees, as well as decreases in the amplitude of M-ERG a- and b-waves and in the retinal thickness in the macular region. The mixed Stargardt's dystrophy group was characterized by reductions in the retinal density of an electrical response of a P1 component, in the amplitude of N1 and P1 components in the entire posterior pole in the area of 0 to 32 degrees, as well as decreases in the a- and b-waves of M-ERG, photopic, scotopic, and mixed ERG; the lowered retinal thickness was found in the foveal and parafoveal regions.