Publications by authors named "E V Rechkina"
We evaluated the performance of rapid antigen (RAg) and antibody (RAb) microfluidic diagnostics with serial sampling of 71 participants at 6 visits over 2 months following severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection. Rapid tests showed strong agreement with laboratory references (κAg = 81.0%; κAb = 87.
View Article and Find Full Text PDFBackground: Guidelines for SARS-CoV-2 have relied on limited data on duration of viral infectiousness and correlation with COVID-19 symptoms and diagnostic testing.
Methods: We enrolled ambulatory adults with acute SARS-CoV-2 infection and performed serial measurements of COVID-19 symptoms, nasal swab viral RNA, nucleocapsid (N) and spike (S) antigens, and replication-competent SARS-CoV-2 by viral growth in culture. We determined average time from symptom onset to a first negative test result and estimated risk of infectiousness, as defined by positive viral growth in culture.
Article Synopsis
- A randomized clinical trial was conducted in Kenya to evaluate the efficacy of single-dose nonavalent and bivalent HPV vaccines against a meningococcal vaccine among women aged 15 to 20.
- The results indicated that both the nonavalent and bivalent HPV vaccines had very high efficacy rates (97.5%) in preventing persistent infections of HPV types 16 and 18, while significantly fewer infections occurred in the HPV vaccine groups compared to the meningococcal vaccine group.
- Overall, the study supports the potential for single-dose HPV vaccination to simplify vaccination processes and decrease healthcare costs while maintaining strong protective effects against targeted HPV infections.
Article Synopsis
- The study compares different swab types and collection sites for testing SARS-CoV-2, focusing on the effectiveness of self-collected swabs from the anterior nares and tongue compared to standard nurse-collected nasopharyngeal swabs.
- Results show that anterior nares swabs had higher diagnostic sensitivity using RT-PCR and antigen testing than tongue swabs, with sensitivities of 91-100% against viral culture.
- The findings suggest that self-collection of anterior nares specimens could serve as a viable alternative for SARS-CoV-2 testing in certain situations.
Background: HPV infection is the primary cause of cervical cancer, a leading cause of cancer among women in Kenya and many sub-Saharan African countries. High coverage of HPV vaccination is a World Health Organization priority to eliminate cervical cancer globally, but vaccine supply and logistics limit widespread implementation of the current two or three dose HPV vaccine schedule.
Methods: We are conducting an individual randomized controlled trial to evaluate whether a single dose of the bivalent (HPV 16/18) or nonavalent (HPV 16/18/31/33/45/52/58/6/11) HPV vaccine prevents persistent HPV infection, a surrogate marker for precancerous lesions and cervical cancer.