Publications by authors named "E V Pomerantsev"
Importance: Disease characteristics of genetically mediated coronary artery disease (CAD) on coronary angiography and the association of genomic risk with outcomes after coronary angiography are not well understood.
Objective: To assess the angiographic characteristics and risk of post-coronary angiography outcomes of patients with genomic drivers of CAD: familial hypercholesterolemia (FH), high polygenic risk score (PRS), and clonal hematopoiesis of indeterminate potential (CHIP).
Design, Setting, And Participants: A retrospective cohort study of 3518 Mass General Brigham Biobank participants with genomic information who underwent coronary angiography was conducted between July 18, 2000, and August 1, 2023.
Background: The ability to non-invasively measure left atrial pressure would facilitate the identification of patients at risk of pulmonary congestion and guide proactive heart failure care. Wearable cardiac monitors, which record single-lead electrocardiogram data, provide information that can be leveraged to infer left atrial pressures.
Methods: We developed a deep neural network using single-lead electrocardiogram data to determine when the left atrial pressure is elevated.
Background: Prior studies have established the impact of sex differences on pulmonary arterial hypertension (PAH). However, it remains unclear whether these sex differences extend to other hemodynamic subtypes of pulmonary hypertension (PH).
Methods: We examined sex differences in PH and hemodynamic PH subtypes in a hospital-based cohort of individuals who underwent right heart catheterization between 2005-2016.
Article Synopsis
- Right ventricular (RV) dysfunction is linked to higher mortality in various heart diseases, and this study investigates the unclear impact of obesity on RV function and outcomes.
- Analyzing over 8,200 patients who underwent right heart catheterization from 2005 to 2016, the study found that higher body mass index (BMI) correlates with poorer RV function indices.
- The findings highlight that RV dysfunction significantly increases the risk of mortality and heart failure hospitalization, with this risk being greater for individuals with higher BMI.
Introduction: The classification and management of pulmonary hypertension (PH) is challenging due to clinical heterogeneity of patients. We sought to identify distinct multimorbid phenogroups of patients with PH that are at particularly high-risk for adverse events.
Methods: A hospital-based cohort of patients referred for right heart catheterization between 2005-2016 with PH were included.