Effect of Perindopril/Indapamide on Cerebral Blood Flow in Middle-Aged, Treatment-Naïve Patients with Hypertension.

Introduction: The relationship between blood pressure (BP) and cerebral blood flow (CBF) is not fully understood. This study evaluated the impact of a perindopril arginine/indapamide (Pa/I) single-pill combination (SPC) on CBF in middle-aged patients.

Methods: A total of 22 treatment-naïve patients with essential hypertension and at least one hypertension-mediated organ damage and 41 healthy controls were enrolled.

[Cognitive functions, emotional status, MRI measurements in treatment-naïve middle-aged patients with uncomplicated essential arterial hypertension].

Aim: To study cognitive functions, anxiety and depression levels, 24-hour blood pressure (BP) profile, cerebral blood flow (CBF) perfusion in treatment-naive middle-aged patients with uncomplicated essential arterial hypertension (EAH) depending on the white matter hyperintensities (WMH) burden.

Material And Methods: Forty-one hypertensive patients (mean age 46.2±4.

[Angiogenesis mechanisms in the formation of structural changes of brain tissue in patients with progressive cerebrovascular disease].

Aim: To study the correlation between expressiveness of focal changes of brain tissue and VEGF and MCP-1 levels in plasma and blood serum of patients with chronic cerebral ischemia (CCI).

Material And Methods: Markers of inflammation (MCP-1, CRP) and angiogenesis (VEGF) in serum and blood plasma of 35 patients with CCI depending on expressiveness of structural changes of brain substance according to MRI were investigated.

Results: The increase in MCP-1 and CRP content in blood serum and simultaneous decrease in VEGF level in serum and blood plasma were correlated with the increase in the number of focal changes of substance of the brain in patients with CCI.

[Magnetic resonance characteristics of minor focal cortical dysplasia in children].

The paper presents data on rare "obscure" forms of cortical dysplasias that play, nevertheless, an important role in the genesis of epilepsy in children. Pseudoschizencephalic phenomena of cortical organization (the straightened sulcus) and two dismigration defects (annular convolution and local simplifications of the pattern of sulci) are characterized. General information on the essence of this problem in Russian and foreign publications is presented.