[Metilin Improves Сardiac Function in Rabbits With Chronic Heart Failure].

Aim: To study effects of intravenous infusion of a cardioprotective drug metilin, developed at the "National Medical Research Center of Cardiology" on indices of cardiac function in rabbits in vivo after prolonged administration of doxorubicin.

Materials And Methods: Animals of the experimental group were intravenously injected with doxorubicin (2 mg / kg once a week) for 8 weeks, animals of the control group received the same volume of saline. Myocardial damage was characterized by an increase in concentration of malondialdehyde (MDA), troponin (TnI) and MB-fraction of creatine kinase (CK-MB) in venous blood and by disturbances in the left ventricle (LV) structure at morphological examination.

In Vitro Study of Influence of Au Nanoparticles on HT29 and SPEV Cell Lines.

Cell culture models are excellent tools for potential toxicity of nanoparticles and fundamental investigations in cancer research. Thus, information about AuNP potential toxicity and effects on human health is necessary for the use of nanomaterials in clinical settings. The aim of our research is to examine the effects of AuNPs on the epithelial origin cell lines: continuous and oncogenic.

Effects of millimeter-wave electromagnetic exposure on the morphology and function of human cryopreserved spermatozoa.

Exposure of human cryopreserved spermatozoa to millimeter-wave electromagnetic radiation of 0.03 mW/cm2 density for 5 min in normozoospermia and for 15 min in asthenozoospermia lead to increase of the fraction of mobile spermatozoa without impairing the membrane integrity and nuclear chromatin status and without apoptosis generation.

Efficiency of transplantation of human placental/umbilical blood cells to rats with severe spinal cord injury.

The effects of a single intravenous injection of human umbilical blood were studied on the model of severe spinal cord contusion injury in rats. Rats receiving no umbilical blood (spontaneous recovery) served as the control. All rats exhibited pronounced hind limb paraplegia and autonomic dysfunction of pelvic organs after the injury.

Ultrastructure of rabbit myocardium in the late period of immobilization stress.

Ultrastructure of working myocardium was studied in rabbits subjected to 70-day immobilization in narrow cages excluding active movements. The structure of working cardiomyocytes, nervous apparatus, and microvascular bed in auricles were studied. Particular attention was focused on intercalated disks in muscle fibers, where separation of fasciae adherents was observed, while desmosomes in the lateral area of these contacts were preserved.