Publications by authors named "E V Olekhnovich"
Antimicrobial resistance poses a serious threat to global public health. The COVID-19 pandemic underscored the need to monitor the dissemination of antimicrobial resistance genes and understand the mechanisms driving this process. In this study, we analyzed changes to the oropharyngeal and fecal resistomes of patients with COVID-19 undergoing therapy in a hospital setting.
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- The study focuses on how gut microbiota, particularly commensal bacteria like lactobacilli, interact with the host immune system's cytokines, which are critical in managing inflammation and gut health.
- Using next-generation RNA sequencing, researchers examined the transcriptional responses of lactobacillus strains K32 and R19-3 to various cytokines, revealing significant changes in gene expression linked to metabolism and stress response, especially upon exposure to IL-8 and IL-10.
- The findings highlight a complex adaptation mechanism where these bacteria adjust their gene expression in response to inflammatory signals, paving the way for potential probiotic therapies for conditions like inflammatory bowel disease (IBD).
Article Synopsis
- Inflammatory bowel diseases involve ongoing inflammation in the intestines and changes in gut microbiota, which can be influenced by outer membrane vesicles (OMVs) that contain polysaccharide A (PSA).
- The study used a mouse model of intestinal colitis induced by sodium dextran sulfate (DSS) and examined the effects of OMV treatment by assessing disease severity and gut tissue health through disease activity index (DAI) and histology.
- Results indicated that OMV treatment improved intestinal healing and altered microbiota composition, highlighting OMVs’ potential as both anti-inflammatory agents and facilitators of microbiota recovery.
Sweet-tasting proteins (SPs) are proteins of plant origin initially isolated from tropical fruits. They are thousands of times sweeter than sucrose and most artificial sweeteners. SPs are a class of proteins capable of causing a sweet taste sensation in humans when interacting with the T1R2/T1R3 receptor.
View Article and Find Full Text PDFImmunotherapy has proven to be a boon for patients battling metastatic melanoma, significantly improving their clinical condition and overall quality of life. A compelling link between the composition of the gut microbiome and the efficacy of immunotherapy has been established in both animal models and human patients. However, the precise biological mechanisms by which gut microbes influence treatment outcomes remain poorly understood.
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