The effect of fenigidine on calcium efflux from the frog heart was studied. In Ringer solution containing 10(-7) and 10(-5) M fenigidine, the efflux of Ca2+ was 0.081 and 0.
View Article and Find Full Text PDFA 40-minute perfusion of the frog ventricular strip with a hypoxic Ringer solution brings about a decline in action potential duration by 37 plus or minus 10% whereas the contractility is completely suppressed by that time. The time constant of the contractility exponential decline constitutes 8 plus or minus 2 min. the effect of hypoxia is reversible.
View Article and Find Full Text PDFThe dose-inward current relationship for calcium channel blocking ions of Ni, Co, Mn and Mg was studied by means of intracellular dialysis and voltage clamp in isolated neurons from the mollusc Limnea stagnalis. For all the four ions the effect was described by the Langmuir isotherm with KMn = 0.36 +/- 0.
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