Publications by authors named "E V Matveev"
Recent advancements in experimental and computational methods for RNA secondary structure detection have revealed the crucial role of RNA structural elements in diverse molecular processes within living cells. It has been demonstrated that the secondary structure of the entire viral genome is often responsible for performing crucial functions in the viral life cycle and also influences virus evolution. To investigate the role of viral RNA secondary structure, alongside experimental techniques, the use of bioinformatics tools is important for analyzing various secondary structure patterns, including hairpin loops, internal loops, multifurcations, external loops, bulges, stems, and pseudoknots.
View Article and Find Full Text PDFMany viruses, including SARS-CoV-2, the coronavirus responsible for the COVID-19 pandemic, enter host cells through a process of cell-viral membrane fusion that is activated by proteolytic enzymes. Typically, these enzymes are host cell proteases. Identifying the proteases that activate the virus is not a simple task but is important for the development of new antiviral drugs.
View Article and Find Full Text PDFObjectives: Mixed-phenotype acute leukemia (MPAL) is a rare disease associated with difficulties in the correct lineage assignment of leukemic cells. One of the least common subtypes within this category is characterized by the simultaneous presence of B- and T-lineage-defining antigens. Each case of suspected B/T MPAL should be considered in light of all available laboratory and clinical data to avoid misdiagnosis.
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- - The virus SARS-CoV-2 uses its spike protein to enter human cells by binding to the angiotensin-converting enzyme 2 (ACE2) receptor, followed by cleavage by specific host proteases such as furin and protease serine 2, which facilitate membrane fusion.
- - This study employed a bioinformatics approach to analyze 169 human proteases that can potentially cleave the spike protein, identifying several families of proteases that cleave important sites on the spike protein and influence its entry into the cell.
- - A particular focus was given to the potential cleavage site at the K790 position, where cleavage could mimic other influential cleavages, leading to significant changes in the spike protein's structure and
Article Synopsis
- This study investigates the complexation of lead(II) and cobalt(II) with specific derivatives of the -decaborate anion that feature azido groups, using ligands like 1,10-phenanthroline and 2,2'-bipyridyl.
- The research leads to the isolation and analysis of mononuclear and binuclear lead complexes, identified through methods like IR spectroscopy and single-crystal X-ray diffraction.
- Notably, for the first time, newly characterized complexes show that the boron cluster can coordinate with lead via pendant nitrogen groups, expanding the understanding of metal-boron interactions.