[The short form of heparin-binding EGF-like growth factor. Part II].

The structure of monkey (Chlorocebus aethiops) heparin-binding EGF-like growth factor (HB-EGF) gene has been investigated in this work in comparison with the known structure of human gene. It was shown that HB-EGF short form (SF-HB-EGF) specific exon 3a is mapped between exons 3 and 4 at distance 700 b.p.

[A short form of the heparin-binding EGF-like growth factor with a changed EGF domain].

In all secreted proteins related to the epidermal growth factor (EGF), EGF domains that occur in a mature factor are each encoded by two exons, and those that do not, by one exon. During splicing, additional exon 3a can be inserted between exons 3 and 4, which code for the EGF domain of the mature heparin-binding EGF-like growth factor (HB-EGF). The resulting mRNA codes for the short form of HB-EGF (SF HB-EGF), which retains the signal peptide, the propeptide, and the heparin-binding domain.

[Two forms of precursors of a heparin-binding EGF-like growth factor-diphtheria toxin receptor].

A new mRNA coding for the heparin-binding EGF-like growth factor (HB-EGF) was found in Vero cells. The corresponding cDNA had C-156 in place of T, which resulted in a loss of the NheI site and a substitution of Leu-33 with Pro in the HB-EGF precursor. The known and new forms of the precursor were accordingly termed L and P.

[Seasonal changes in the human constant electrical field in various age groups].

Seasonal changes of the constant electric field of healthy people of various age groups were studied. The constant electric field was shown to be characterized by a fine structure of distribution of electric potential differences (EPD) along the skin in relation to a referent point located on the neck in the intersection region of trapeziform and clavicular-nipple muscles. The constant electric field of the people of all ages undergoes seasonal changes involving displacement of all EPD values to the positive region during autumn-winter period as compared to the spring-summer one.

[The kinetics of a permanent electrical field during the knitting of mandibular fractures].

The authors' findings helped develop schedules of osteogenesis stimulation in cases when this process was shifted towards resorption (periodontosis), as well as develop a method for determining periodontitis stage and the ability of the body to regeneration.