Analysis of Corneal Biomechanical Properties in Different Keratotopographic Patterns of Keratoconus.

Purpose: To analyze the frequency of main keratotopographic patterns at the 1, 2, and 3 stages of keratoconus and investigate corneal biomechanical properties across different patterns.

Methods: The study comprised two stages. The first stage was computational-experimental, where we utilized COMSOL Multiphysics® software (COMSOL AB, Stockholm, Sweden) to mathematically model corneal mechanical behavior under intraocular pressure and pulsed air jet action in both normal and keratoconic conditions.

Analysis of the results of modified personalized topographically and tomographically oriented technique of ultraviolet corneal collagen crosslinking.

Purpose: The study aims to develop a modified personalized topographically and tomographically oriented technique of ultraviolet corneal collagen cross-linking (UVCXL) to affect the area of the cornea with weakest biomechanical properties as determined by mathematical modeling.

Material And Methods: Modeling of the biomechanics of keratoconic cornea under conditions of external diagnostic action was done using COMSOL Multiphysics software. Finite-element analysis procured 3D images of stress/deformation distribution pattern throughout the cornea.