[Role of changes in the transmembrane ion currents in pathological states of the body].

Modern data of study of transmembrane ions currents (through the sodium-potassium- and calcium-channels) in the mechanism of pathological pain syndromes were reviewed. Tetrodotoxyn-resistant sodium currents, abnormal combinations of different types of sodium-channels during the inflammation, neuropathies (syndromes hyperalgesii and allodonii) and diabetic neuropathy analyzed. The role of pain sensitivity transmitters was demonstrated.

[Endoplasmic reticulum and mitochondria as elements of mechanism of intracellular signaling in neurons].

The temporal and spatial characteristics of a transitory increase in free Ca2+ ("calcium signals") concentration were determined in various types of the mice and rat neurones. Intracellular structures: endoplasmatic reticulum and mitochondria, were shown to play a major part in formation of these signals, the structures being able to absorb the Ca2+ ions from cytosol and release them back. The contribution of these processes proves rather varying depending on internal organisation and functional assignment of a neurone.

[Various biochemical parameters in serum of pregnant women carrying fetuses with various congenital defects of development].

The number of changes in some maternal serum biochemical parameters for some congenital malformations are presented. In all pregnancies we observed low levels of LAT, AST, CPK, HBD, AP and high levels of GGTP, THY, amylase. These data demonstrate total depression in metabolism of women with an affected fetus.

[Pathogenesis of atherosclerosis in diabetes mellitus. The role of insulin resistance and hyperinsulinemia].

The review summarizes data about interconnection between atherosclerosis and diabetes mellitus. Special attention is paid to their joint developmental factors such as hyperinsulinemia and insulin resistance. It is shown that hyperinsulinemia may form an independent risk factor.

[Effect of calcium antagonists on the hemodynamic and pancreatic secretory parameters in diabetes mellitus].

Data are presented concerning the basal levels of parathormone and calcitonin and the effect of dihydropyridine derivatives on the characteristics of haemodynamics as well as pancreatic secretory activity in patients with diabetes mellitus. It is shown that in diabetic patients with hypertension a single administration of the drugs induces vasodilatation which causes lowering of systolic and diastolic blood pressure. In patients with diabetes mellitus in combination with hypertension, heart coronary disease and obvious peripheral angiopathy (similar procedure) no peripheral vasodilatation was observed.