[MIKAMINOM ANTIFUNGAL THERAPY IN NEWBORNS AND INFANTS WITH SURGICAL PATHOLOGY].

Prolonged empiric and etiotropic therapy of multidrug-resistant or pan-resistant bacterial flora in different gestation age newborns has led to the growth of resistant fungalflora in intencive care units (ICU). According to risk factors and rating scales every child of ICU undergoing the abdominal cavity surgery is threatened the development of a fungal infection and requires antifungal therapy appointment or causal prophylactic. In recent years, before the advent of medications of the group of echinocandins, therapy of invasive fungal infections has been a challenge.

[THE DIFFICULTY IN DIAGNOSING OF RARE FORMS OF CONGENITAL DISORDERS OF AMINO ACID METABOLISM IN INFANTS (HEREDITARY TYROSINEMIA)].

Diagnosis of amino acid metabolism disorders according to the clinics without laboratory diagnosis is almost impossible in infants with a history of neonatal and/or premorbid background and multi-organ failure. Mortality due to hereditary tyrosinemia type I is greater than 90%.

[Algorithm of therapy in neonates with developmental malformations depending on causes and severity of illness in the intensive care unit].

The results of treatment for congenital malformations requiring emergency interventions depend on the timeliness and correctness of diagnosis of a defect, on the performance of resuscitative and surgical interventions, the correct evaluation of a neonate's condition at different stages of treatment. The score rating of the patient's condition is objective and may be an evidence-based medicine tool. Prior to the emergence of the universal scale, many authors used their own developments.