In this paper we study one-dimensional quantum Ising spin chains in an external magnetic field close to an integrable point. We concentrate on the dynamics of the slowest operator that plays a key role at the final period of thermalization. We introduce two independent definitions of the slowest operator: local and translationally invariant ones.
View Article and Find Full Text PDFIdentification of molecular targets and mechanism of action is always a challenge, in particular - for natural compounds due to inherent chemical complexity. BP-Cx-1 is a water-soluble modification of hydrolyzed lignin used as the platform for a portfolio of innovative pharmacological products aimed for therapy and supportive care of oncological patients. The present study describes a new approach, which combines screening of potential molecular targets for BP-Cx-1 using Diversity Profile - P9 panel by Eurofins Cerep (France) with a search of possible active components in ChEMBL - manually curated chemical database of bioactive molecules with drug-like properties.
View Article and Find Full Text PDFFiziol Zh SSSR Im I M Sechenova
January 1991
The effect of muscular activity (MA) on the amount of different classes of leukocytes in the blood, concentrations of myeloperoxidase and lysozyme in the blood plasma, and neutrophils and phagocytosis parameters of these cells, were studied in rats. The MA resulted in a decrease of marker proteins (myeloperoxidase and lysozyme) concentration in neutrophils and an increase of their concentrations in the blood plasma. The neutrophil phagocytic activity decreased.
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