Polymer-loaded hydrogels serve as depots for lactate and mimic "cold" tumor microenvironments.

The burgeoning field of biomaterials for immunotherapy has aided in the understanding of foundational mechanisms of cancer immunology. In particular, implantable biomaterials can be engineered to investigate specific aspects of the tumor microenvironment either singularly or in combination. Of note, the metabolite - lactate, a byproduct of anaerobic glycolysis, is known to reprogram immune cells, resulting in increased tumor survival.

[Occupational skin diseases as social-economic problem].

The article deals with factors causative of high social-economic importance of occupational skin diseases, presents parameters of occupational skin diseases prevalence, exogenous and endogenous risk factors of occupational skin diseases. This conditions appear to have negative influence on everyday life and occupational activities of the patients, induce lower quality of life and work performance. Pathogenesis and clinical signs, laboratory values characterizing atopic and allergic dermatitis are discussed.