High importance of indirect evolutionary rescue in a small food web.

Evolutionary rescue may allow species to survive environmental change, but how this mechanism operates in food webs is poorly understood. Here, the evolutionary rescue was investigated in a small model food web, systematically allowing the evolution of each single species in order to reveal how its adaptation affects the persistence of itself and others. The impact of evolution was highly species-specific and not necessarily positive: only one species, the specialist predator, consistently had a positive impact on overall persistence.

Shifts from cooperative to individual-based predation defense determine microbial predator-prey dynamics.

Predation defense is an important feature of predator-prey interactions adding complexity to ecosystem dynamics. Prey organisms have developed various strategies to escape predation which differ in mode (elude vs. attack), reversibility (inducible vs.

The double-edged sword of inducible defences: costs and benefits of maladaptive switching from the individual to the community level.

Phenotypic plasticity can increase individual fitness when environmental conditions change over time. Inducible defences are a striking example, allowing species to react to fluctuating predation pressure by only expressing their costly defended phenotype under high predation risk. Previous theoretical investigations have focused on how this affects predator-prey dynamics, but the impact on competitive outcomes and broader community dynamics has received less attention.

Real-World Effectiveness of Reslizumab in Patients With Severe Eosinophilic Asthma - First Initiators and Switchers.

Background: Reslizumab, a biologic targeting IL-5, has been shown to reduce asthma exacerbations and maintenance oral corticosteroid use in randomized controlled trials and pre-post studies in patients with severe eosinophilic asthma. However, real-world effectiveness data of reslizumab are scarce, and it is unknown whether reslizumab has added value after switching from another type 2 biologic.

Objective: To evaluate (1) the real-world effectiveness of reslizumab on severe asthma exacerbations, maintenance oral corticosteroid use, and overall treatment response, both in biologic-naive patients who initiated reslizumab and in those who switched from another type 2 biologic; and (2) physicians' experience with reslizumab treatment.

Quantitative and Predictive Modelling of Lipid Oxidation in Mayonnaise.

Food emulsions with high amounts of unsaturated fats, such as mayonnaise, are prone to lipid oxidation. In the food industry, typically accelerated shelf life tests are applied to assess the oxidative stability of different formulations. Here, the appearance of aldehydes at the so-called onset time, typically weeks, is considered a measure for oxidative stability of food emulsions, such as mayonnaise.