[Long-term and seasonal dynamics of vitamin D supply indicators for the population of the Western Siberia region].

Despite the active study of vitamin D, today the problem of its insufficient supply remains relevant both in Russia and throughout the world. In our country, the situation is affected by the geographical, climatic, as well as ethnic and cultural characteristics of each region. It is of interest to assess the temporal and territorial characteristics of the population's sufficiency.

[Provision of vitamin D in the adult population of Western Siberia: a population-based study].

The results of research in recent years indicate a widespread low intake of vitamin D, its deficiency or lack among the population of many countries around the world. It is of interest to study vitamin D status of the population living at different geographic latitudes and depending on socio-demographic characteristics. of the research is to analyze vitamin D status of the adult population living in the Omsk Region over the age of 18 in different seasons of the year.

Neuron-specific overexpression of core clock genes improves stress-resistance and extends lifespan of Drosophila melanogaster.

Gene expression is much altered in aging. We observed age-dependent decline of core clock genes' expression in the whole body of the fruit fly. We hypothesized that inducible overexpression of clock genes (cry, per, tim, cyc and Clk) in the nervous system can improve healthspan of D.

Transcriptome analysis reveals mechanisms of geroprotective effects of fucoxanthin in Drosophila.

Background: We have previously showed that the carotenoid fucoxanthin can increase the lifespan in Drosophila melanogaster and Caenorhabditis elegans. However, the molecular mechanisms of the geroprotective effect of fucoxanthin have not been studied so far.

Results: Here, we studied the effects of fucoxanthin on the Drosophila aging process at the molecular and the whole organism levels.

Clonal chromosomal and genomic instability during human multipotent mesenchymal stromal cells long-term culture.

Background Aims: Spontaneous mutagenesis often leads to appearance of genetic changes in cells. Although human multipotent mesenchymal stromal cells (hMSC) are considered as genetically stable, there is a risk of genomic and structural chromosome instability and, therefore, side effects of cell therapy associated with long-term effects. In this study, the karyotype, genetic variability and clone formation analyses have been carried out in the long-term culture MSC from human gingival mucosa.