Publications by authors named "E V Derkach"
[Social and economic burden of stroke in Russian Federation].
Zh Nevrol Psikhiatr Im S S Korsakova
September 2023
Objective: The purpose of this study was to assess the annual socio-economic burden of stroke in the Russian Federation from the position of the state.
Material And Methods: Based on official statistics on morbidity and mortality due to stroke (2019), the results of a survey of patients or caregivers (680 respondents) and cost indicators of 2022, the social and economic burden of stroke during the 1st year after the acute period is modeled. All cost estimates are made from the position of the state.
Aim: To analyze the features of drugs provision for special groups of treatment-nave HIV-infected patients initiating antiretroviral treatment with fixed dose combination (FDC) for once-daily single-tablet regimen, in Russian healthcare setting.
Materials And Methods: We studied the regulatory legal documents governing the provision of antiretroviral drugs in Russia and analyzed the Russian Program of State Guarantees to determine the inclusion of the investigated FDCs in the lists of regional benefits, as well as regional and federal procurement of these drugs in 2020 and 2021. We compared costs of first line therapy for special groups using FDCs regimens per year in case of regional purchases or centralized purchases.
Background: In Russia, before 2022, the list of vital and essential drugs for HIV-infected patients previously untreated with antiretroviral drugs included the fixed-dose combination rilpivirine/tenofovir disoproxil fumarate/emtricitabine (RPV/TDF/FTC) but not doravirine/tenofovir disoproxil fumarate/lamivudine (DOR/TDF/3TC).
Methods: An indirect comparison of the efficacy of DOR/TDF/3TC and RPV/TDF/FTC defined by virologic suppression (HIV-1 RNA of <50 copies/mL at week 48) was made. The per-patient drug costs over 1 year were compared in a cost-minimization analysis.
Article Synopsis
- Malignant tumors of the gallbladder are uncommon, with adenocarcinoma as the most prevalent type, while carcinosarcoma is an extremely rare variant that accounts for less than 1% of gallbladder cancers.
- Carcinosarcoma can occur in various organs, but it is typically found in the uterus, and its diagnosis is challenging due to its unique combination of epithelial and mesenchymal components.
- As there have been fewer than 100 cases documented in English literature, this article aims to enhance awareness among healthcare professionals to improve diagnosis, treatment, and survival rates for patients with this rare condition.
The paper proposes a game-theoretic model of interaction between investors and innovators, taking into account the existence of so-called "fake" innovators offering knowingly unprofitable projects. The model is a Bayesian non-cooperative, repetitive game with recalculated payments and partly unobservable player types. It allows quantifying the parameters of the strategy for all player types to find equilibrium solutions.
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