Publications by authors named "E V Denisov"
Undifferentiated pleomorphic sarcoma (UPS) is a highly malignant mesenchymal tumor that ranks as one of the most common types of soft tissue sarcoma. Even though chemotherapy increases the 5-year survival rate in UPS, high tumor heterogeneity frequently leads to chemotherapy resistance and consequently to recurrences. In this study, we characterized the cell composition and the transcriptional profile of UPS with resistance to chemotherapy at the single cell resolution.
View Article and Find Full Text PDFTransiently elevated expression of different forms of brain-derived neurotrophic factor in the neonatal medial prefrontal cortex affected anxiety and depressive-like behaviors in adolescence.
PeerJ
December 2024
Article Synopsis
- BDNF (Brain-derived neurotrophic factor) is vital for nerve cell growth and survival, with forms that bind to different receptors affecting brain development, especially during the neonatal period.
- Disruptions in BDNF levels during this critical time can lead to long-term behavioral issues, including increased anxiety and depression in adolescents.
- The study found that elevated levels of mature BDNF contributed to these behaviors, while mutant BDNF led to opposite transcriptional changes, suggesting a significant link between BDNF variations and the development of neurobehavioral disorders.
Soft tissue sarcomas (STS) are heterogeneous and aggressive tumors, originating in connective tissues embryologically derived from the mesenchyme. Due to their rarity, crucial information about their biology is still lacking. In recent years, single-cell and spatial analyses have opened up new horizons in oncology, leading to the possibility of characterizing the internal architecture of the tumor at the single-cell and spatial levels.
View Article and Find Full Text PDFTongue cancer at a young age demonstrates an increase in incidence, aggressiveness, and poor response to therapy. Classic etiological factors for head and neck tumors such as tobacco, alcohol, and human papillomavirus are not related to early-onset tongue cancer. Mechanisms of development and progression of this cancer remain unclear.
View Article and Find Full Text PDFMost studies on CTCs have focused on isolating cells that express EpCAM. In this study, we emphasize the presence of EpCAM-negative and EpCAM CTCs, in addition to EpCAM CTCs, in early BC. We evaluated stem cell markers (CD44/CD24 and CD133) and EMT markers (N-cadherin) in each subpopulation.
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