[Palivizumab: four seasons in Russia].

In 2010, the Russian Federation (RF) registered palivizumab--innovative drug, based on monoclonal antibodies for passive immunization of seasonal respiratory syncytial virus (RSV) infection in children of disease severe progress risk group, which include primarily premature infants, children with bronchopulmonary dysplasia and hemodynamically significant congenital heart disease. Currently, palivizumab is included in the list of recommended medicines and medical care standards of different countries, including Russia. In the review the results of Russian research on the progress of RSV infection, its epidemiology and immunization experience gained over the 2010-2014 period are summarized in relation to the foreign data.

[The thoracoscopy in complex treatment of non-specific pleural empyema and purulent-destructive diseases of lungs].

The results of treatment of 697 patients with different kinds of non-specific pleural empyema and gangrenous lesions of lungs are presented in the article. Need for complex and differentiated treatment of pleural empyema with obligatory use of thoracoscopy is revealed. High efficiency of early thoracoscopic sanitation improving outcomes and length of hospital stay is proved.

[Influence of ionizing radiation on the parameters of oxidative stress markers in the rat liver and thymus].

Influence of ionizing radiation on the parameters of oxidative stress markers in the liver and thymus of the rats exposed to gamma-radiation 60Co at a doze of 4 Gy was investigated. The animals were decapitated on the 1, 4, 7, 10, 14, 22 and 30th day after irradiation and cell suspensions from the liver and thymus were obtained. After centrifugation, the content of MDA, the spontaneous and NADH-induced synthesis of superoxide anion radical of oxygen, the content of total and free iron were determined in the cellular sediment and centrifugate containing intercellular fluid.

[Personalized reamberin therapy in patients with decompensated LADA 1.5 diabetes mellitus].

The aim of the study was to develop a new strategy of dosing a Reamberine 1,5% infusion solution on an individual basis for patients with LADA 1.5 diabetes mellitus (DM) and new methods for estimating the regulation and functioning of metabolic pathways associated with the production and transformation of succinic acid. The use of Reamberin led to the reduction of average, maximum and minimum blood glucose and HBA1c levels.

A prospective, open-label, non-comparative study of palivizumab prophylaxis in children at high risk of serious respiratory syncytial virus disease in the Russian Federation.

Background: Respiratory syncytial virus (RSV) is a leading cause of lower respiratory tract infections (LRTIs) in children globally. Predisposing conditions for the development of serious RSV disease include preterm infants and those with cardiopulmonary illness, including congenital heart disease (CHD) and bronchopulmonary dysplasia (BPD). No vaccine is currently approved for the prevention of RSV infection.