Association of the Gene's Single-Nucleotide Variant Rs1815739 (R577X) with Sports Qualification and Competitive Distance in Caucasian Athletes of the Southern Urals.

Unlabelled: An elite athlete's status is associated with a multifactorial phenotype depending on many environmental and genetic factors. Of course, the peculiarities of the structure and function of skeletal muscles are among the most important characteristics in the context of athletic performance.

Purpose: To study the associations of SNV rs1815739 (C577T or R577X) allelic variants and genotypes of the gene with qualification and competitive distance in Caucasian athletes of the Southern Urals.

Candidate Genes of Regulation of Skeletal Muscle Energy Metabolism in Athletes.

All biological processes associated with high sports performance, including energy metabolism, are influenced by genetics. DNA sequence variations in such genes, single nucleotide variants (SNVs), could confer genetic advantages that can be exploited to achieve optimal athletic performance. Ignorance of these features can create genetic "barriers" that prevent professional athletes from pursuing a career in sports.

Occurrence of the birds of the Middle Volga Region (South-East of the European part of Russia).

Background: Birds are the most numerous and widespread group of higher vertebrates. Due to the peculiarities of their biology, birds play an important role in nature and in human life.Ornithological studies described in this publication were conducted in seven regions of the Middle Volga Region (Chuvashia, Mordovia, Tatarstan, Samara, Nizhny Novgorod, Ulyanovsk and Penza Regions) from 1978 to 2021.

The "Angiogenic Switch" and Functional Resources in Cyclic Sports Athletes.

Regular physical activity in cyclic sports can influence the so-called "angiogenic switch", which is considered as an imbalance between proangiogenic and anti-angiogenic molecules. Disruption of the synthesis of angiogenic molecules can be caused by local changes in tissues under the influence of excessive physical exertion and its consequences, such as chronic oxidative stress and associated hypoxia, metabolic acidosis, sports injuries, etc. A review of publications on signaling pathways that activate and inhibit angiogenesis in skeletal muscles, myocardium, lung, and nervous tissue under the influence of intense physical activity in cyclic sports.

Water-Soluble Heliomycin Derivatives to Target i-Motif DNA.

Heliomycin (also known as resistomycin) is an antibiotic with a broad spectrum of biological activities. However, low aqueous solubility and poor knowledge of its chemical properties have limited the development of this natural product. Here, we present an original scheme for the introduction of aminoalkylamine residues at positions 3, 5, and 7 of heliomycin and, using this, have prepared a series of novel water-soluble derivatives.