Emergency clinicians' use of adult and paediatric sepsis pathways: An implementation redesign using the behaviour change wheel.

Aims: To identify facilitators and barriers and tailor implementation strategies to optimize emergency clinician's use of adult and paediatric sepsis pathways.

Design: A qualitative descriptive study using focus group methodology.

Methods: Twenty-two emergency nurses and ten emergency medical officers from four Australian EDs participated in eight virtual focus groups.

Features of the distribution of the antigens of Kell, Duffy, Kidd, MNS, Lewis, Lutheran blood group systems in blood donors in the Kirov region.

The frequency of occurrence of antigens of the Kell (Kpa, Kpb), Kidd, Duffy, MNS and Lutheran systems in donors of the Kirov region corresponds to the distribution of antigens characteristic of white Europeans. Antigens K (Kell system) and Lea (Lewis system) are detected in the population of the region much less frequently, antigen Leb (Lewis system) - more often than in the population of Europe. The presence of a registry of donors typed according to a wide range of red blood antigens is a prerequisite for the immunohematological safety of blood transfusions.

Role of HLA genes in development of HLA-alloimmunization in blood recipients.

A genetically determined predisposition to the development of HLA-alloimmunization as a result of blood transfusions is associated with the presence of HLA-alleles DRB1*04, DQA1*03:01, DQA1*05:01 and HLA-haplotype DRB1*04-DQA1*03:01-DQB1*03:02 in the genotypes of recipients. The risk of antibody production is reduced in patients with HLA-alleles DRB1*16, DQA1*01:02, DQB1*05:02 and HLA-haplotype DRB1*16-DQA1*01:02-DQB1*05:02.

Immunohematological provision of red blood cells transfusions to alloimmunized recipients (clinical case).

Timely diagnostics of red blood cells (RBC) antibodies and selection of immunologically compatible donors can prevent the occurrence of hemolytic transfusion reactions in recipients of RBC. The article presents an analysis of a clinical case describing the variability of the antibody screening results and the difficulties of individual selection of donors for a alloimmunized patient with myelodysplastic syndrome. The basic immunohematological principles have been formulated to ensure the safety of transfusions in patients with RBC antibodies.

Changes in Number and Antibacterial Activity of Silver Nanoparticles on the Surface of Suture Materials during Cyclic Freezing.

This article presents the results of the 10-fold cyclic freezing (-37.0 °C) and thawing (0.0 °C) effect on the number and size range of silver nanoparticles (AgNPs).