Publications by authors named "E V Brenner"
Introduction: Modification of natural enzymes to introduce new properties and enhance existing ones is a central challenge in bioengineering. This study is focused on the development of Taq polymerase mutants that show enhanced reverse transcriptase (RTase) activity while retaining other desirable properties such as fidelity, 5'- 3' exonuclease activity, effective deoxyuracyl incorporation, and tolerance to locked nucleic acid (LNA)-containing substrates. Our objective was to use AI-driven rational design combined with multiparametric wet-lab analysis to identify and validate Taq polymerase mutants with an optimal combination of these properties.
View Article and Find Full Text PDFBackground: Children with inflammatory bowel disease (IBD) may have diminished serologic response to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) vaccination and increased risk for subsequent severe coronavirus disease 2019 (COVID-19) infection. We sought to describe outcomes among those who developed SARS-CoV-2 infection following vaccination, characterize SARS-CoV-2 antibodies 1 year post-vaccination, and identify factors associated with durable serologic response.
Methods: We recruited children with IBD who received ≥2 doses of SARS-CoV-2 vaccine and prospectively collected data on (1) demographics, IBD characteristics, and therapy and (2) SARS-CoV-2 vaccination, testing, and infection symptoms.
Objective: To increase patients' knowledge and access to genetic carrier screening (GCS) in a gynecologic setting by implementing a protocol to universally offer GCS education and screening to reproductive-age women during the preconception period at gynecologic-related visits.
Design: The model for improvement quality improvement process model was used to guide this initiative.
Local Problem/setting: Screening for genetic disease has been a part of preconception and genetic care for the past 50 years.
Exploring the complex information processes underlying plant behavior.
Plant Signal Behav
December 2024
Article Synopsis
- Newly discovered plant behaviors suggest that plants have complex information processing systems and demonstrate agency and learning, challenging traditional views of their capabilities.
- Research on plant plasticity highlights their responses to environmental factors and the interactions with neighboring plants for resource competition and coordination.
- Emerging climate-smart agricultural practices, informed by a deeper understanding of plant behavior, aim to enhance crop resilience and productivity, benefiting both natural and agricultural ecosystems.