[Complementation of several methods of determining the mutagenic activity of chemicals].

Complementation of some methods for detecting the mutagenic activity of microorganisms, Drosophila, mammals and human cells using cluster analysis was studied. Mutual substitutions of the methods must be taken into account for optimization of the tests-system to detect mutagenic activity of chemicals.

[Statistical analysis and experiment planning in the test for the induction of anomalous sperm in mice].

The work deals with analysis and planning of experiments in one of the testing methods for potential genetic activity of chemicals--in the test for sperm abnormality in mice. A novel way of analysis of experimental data using consecutive scheme of microscopy of preparations has been suggested which came to be more convenient and economically advantageous in routine work.

[Experimental analysis and planning using the Salmonella/microsomes test].

A possible statistical treatment of the results obtained in Salmonella typhimurium TA1950, TA1535, TA1537, TA1538, TA98 and TA100 using the Salmonella/microsomes test was investigated. An analysis of independent repeated experiments pointed to the divergence of the data obtained. Consequently, it has been recommended to carry out the statistical treatment of experimental data within the limits of dispersion analysis with the subsequent use of the Scheffe's method for multiple comparisons.

[Indices for assessing genetic damage induced by chemical compounds. Assessment of the induction of sister chromatid exchange by chemical compounds].

Some preferences of using the new index "number of chromosomes involved in the exchange" in comparison with the standard index "number of SCE per cell" are discussed. The mean probability of the induced involving a chromosome into the exchange is estimated as (formula: see book) where pt and pc are the mean number of chromosomes involved in the exchange divided to the total number of chromosomes in the test and control groups, respectively.