Thio Derivatives of 2(5H)-Furanone as Inhibitors against Bacillus subtilis Biofilms.

Gram-positive bacteria cause a wide spectrum of infectious diseases, including nosocomial infections. While in the biofilm, bacteria exhibit increased resistance to antibiotics and the human immune system, causing difficulties in treatment. Thus, the development of biofilm formation inhibitors is a great challenge in pharmacology.

[Molecular mechanism of homologous recombination in meiosis: origin and biological significance].

Sexual reproduction prevails among eukaryotic organisms. The problem of advantage of sexual reproduction over asexual reproduction remains a subject of not stopping discussions. According to one of the hypotheses, sexual reproduction and homologous recombination which accompanies gamete formation during meiosis has arisen to increase genetic variability and, as consequence, a fitness of organisms.

[The effect of extracellular metabolites on the frequency of Thy+ revertants in Salmonella typhimurium populations].

There is convincing evidence that adaptation and survival processes in bacterial populations depend on cell-to-cell interactions. Our studies showed that the frequency of stress-induced His+ reversions in an amino-acid-starved Salmonella typhimurium culture is inversely proportional to cell density in this culture. The effects of cell density and of different culture liquids prepared from cultures varying in physiological age on the frequency of Thy+ revertants were also studied.

[SOS-inducible DNA polymerases and adaptive mutagenesis].

Stability of genomes of living organisms is maintained by various mechanisms that ensure high fidelity of DNA replication. However, cells can reversibly enhance the level of replication errors in response to external factors. As mutable states are potentially involved in carcinogenesis, aging, and resistance for pathogenic agents, the existence of these states is of great importance for human health.

[Study of mutagenic activity of fullerene and some of its derivatives using His+ reversions of Salmonella typhimurium as an example].

The influence of three new derivatives of fullerence C60 ([61]dimethoxyphosphoryl[61]carbethoxy-methano[60]fullerene, [61]-(dimethoxyphosphoryl-[61]-carbmethoxy-methanofullerene, and 1-methyl-2-(3,5-di-tertbutyl-4-hydroxy-phenyl)-3,4-fulleropyrrolidine) on the appearance of His+ reversions in the Salmonella typhimurium strain BA13 was studied. It was ascertained that the effect of fullerene derivatives on the occurrence of mutations depends on the type of the molecular group with which fullerene interacts. The biological effect is determined not only by the action of the group associated with fullerene.