[Study of protective activivty of "Staphylovac-2" vaccine].

Aim: Study the protective properties of "Staphylovac-2" vaccinie.

Materials And Methods: Samples of the vaccine manufactured by SPA "Microgen" based on the developed technology were studied in balb/c mice during 3- and 6-fold immunization schemes. Protective activity of the preparation was determined in experiments with active and passive protection during intraperitoneal infection, seeding of the causative agent from spleen and kidneys during intravenous infection, of animals.

[Genetic characteristics of Staphylococcus aureus No 6. strain--producer of secreted protein-containing compounds possessing protective properties].

Aim: Genotype characteristics of Staphylococcus aureus No 6: strain that is a producer of a protective protein complex.

Materials And Methods: Features of structure of 9 genes, that code synthesis of pathogenicity factors, of S. aureus--spa, coa, sea, seB, sec, pvl, tst-h, mecA and scc-mecA, that are responsible for synthesis of protein A, coagulase, enterotoxins A, B and C, Panton-Valentine toxin (PVL), heat shock syndrome protein, resistance to methicillin and staphylococci chromosomal cassette, respectively, were studied by amplification in PCR of the respective gene fragments with subsequent conduction of direct sequencing.

[Immunogenic properties of experimental production series of Staphylovac-2 vaccine].

Aim: Study experimental production series of Staphylovac-2 by accumulation of specific IgG and safety.

Materials And Methods: Experimental production samples of staphylococci vaccines were studied by the accumulation of specific IgG in sera of immunized BALB/c line mice in EIA. Safety was evaluated in tests of acute and chronic toxicity including pathomorphologic and histologic, hematologic and biochemical studies, studies of the effect on central nervous system.

[Analysis of extracellular proteome of Staphylococcus aureus 6 at the end of exponential growth phase].

Aim: Determine protein specter that Staphylococcus aureus synthesizes and secretes at early growth phase--the exponential phase.

Materials And Methods: Proteins secreted by S. aureus strain 6 into cultivation medium at the end of exponential growth phase (4.

[Automated unit complex for analyzing biomedical signals in a mass population screening system].

Some features of automating processes of biomedical signal analysis are considered. An actual complex of algorithms and programs realized on the homemade hardware is taken as an example. Practical recommendations to improve similar complexes being in current use in outpatient clinics are given.