Publications by authors named "E Uslu"
Since the introduction of H3N2 influenza A viruses in the human population, these viruses have continuously evolved to escape human immunity, with mutations occurring in and around the receptor binding site. This process, called antigenic drift, recently resulted in viruses that recognize elongated glycans that are not abundantly displayed in the human respiratory tract. Such receptor specificities hampered our ability to pick and propagate vaccine strains.
View Article and Find Full Text PDFIs Serum VEGF-A Level an Indicator of Early-Onset Poststroke Depression?
Medicina (Kaunas)
November 2024
Article Synopsis
- - Poststroke depression (PSD) significantly affects quality of life and may be linked to serum vascular endothelial growth factor (VEGF-A) levels, which were investigated in 88 patients with acute ischemic stroke (AIS).
- - The study found that patients with PSD scored worse on cognitive and stroke severity assessments, and while VEGF-A levels were similar across severity groups, the relationship between cognitive function and depression was evident.
- - Results indicate a need for further research with larger, diverse populations to explore whether serum VEGF-A could serve as a predictive marker for early-onset PSD.
Background: Antiphospholipid Syndrome (APS) is one of the most common acquired causes of hypercoagulability. The 2023 American College of Rheumatology (ACR) / European Alliance of Associations for Rheumatology (EULAR) APS Classification Criteria were specified as new APS classification criteria with high specificity for use in observational studies and research. The primary objective of this study was to evaluate the performance of the 2023 ACR/EULAR APS classification criteria in a real-world rheumatology department.
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- The study aimed to compare patients with seronegative and seropositive primary Sjögren's syndrome (pSS) by analyzing their medical records from 2010 to 2023.
- Key findings revealed that seropositive patients exhibited more extraarticular manifestations, while dry mouth was notably more common in seronegative patients.
- Additionally, while the two groups showed similar rates of certain complications, seropositive patients accounted for all the deaths observed in the study.
Keratan sulfate (KS) is a highly complex proteoglycan that has a poly-LacNAc chain that can be modified by diverse patterns of sulfate esters at C-6 positions of galactoside (Gal) and -acetylglucosamine (GlcNAc) residues. Here, a chemo-enzymatic methodology is described that can control the pattern of sulfation at Gal using UDP-Gal-aldehyde as a donor for poly-LacNAc assembly to temporarily block specific sites from sulfation by galactose 6-sulfotransferase (CHST1).
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