Antioxidant and Pro-Oxidant Properties of Selected Clinically Applied Antibiotics: Therapeutic Insights.

Background: The balance between antioxidants and pro-oxidants plays a significant role in the context of oxidative stress, influenced by both physiological and non-physiological factors.

Objectives: In this study, 18 prescribed antibiotics (including doxycycline hydrochloride, tigecycline, rifampicin, tebipenem, cefuroxime, cefixime, potassium clavulanate, colistin, ampicillin, amoxicillin, amikacin, nalidixic acid, azithromycin, pipemidic acid trihydrate, pivmecillinam, aztreonam, fosfomycin sodium, and ciprofloxacin) were subjected to simultaneous determination of antioxidant and pro-oxidant potential to assess if pro-oxidant activity is a dominant co-mechanism of antibacterial activity or if any antibiotic exhibits a balanced effect.

Methods: This study presents a recently developed approach for the simultaneous assessment of antioxidant and pro-oxidant potential on a single microplate in situ, applied to prescribed antibiotics.

Antibacterial Potential of Microwave-Assisted Extraction Prepared Hydrolates from Different Species.

Salvia is a widely used herb that also contains essential oils and other valuable compounds. In this work, the hydrolates of five sp. were evaluated for their potential antimicrobial and antioxidant activity against four bacterial strains.

[Isolation of Listeria ivanovii in Slovakia].

From October 1977 to May 15, 1989 in Slovakia 39 strongly haemolytic strains of L. ivanovii were isolated from a woman after delivery of a stillborn foetus--from the lochiae, placenta and rectal smear, from five symptom-free subjects from the faeces, from the rectal smears of two sheep, from the intestinal contents in the portion of the terminal ileus from 28 free living small terrestrial mammals, one strain from meat--beef steak, from the lungs, liver and kidneys of a dead young sheep and one strain from silage. The strains from the lochiae and placenta as well as those from the organs of sheep were detected already as primocultures on commonly used blood agar, the other strains after varying periods of cold enrichment and subsequent inoculation on a solid selective medium with nalidixic acid and acriflavin.

Ecology and importance of bacterial' species of the family Vibrionaceae.

The bacterial species of the family Vibrionaceae, particularly the species of the genus Aeromonas (A. hydrophila and A. punctata and their subspecies were found to be relatively common in the running surface water in Czechoslovakia (the occurrence of A.