Publications by authors named "E Ulukaya"
Article Synopsis
- The study focuses on developing a new drug, "IHNOCS," aimed at treating Head, Neck, and Oral Cancer by targeting specific proteins to suppress cancer progression.
- Using advanced computational tools, researchers demonstrated that IHNOCS effectively inhibits the KRTAP2-3 protein and modulates TGF-β, which helps to slow down cancer metastasis.
- While the drug shows promising results in theory, it will need to go through further experimental testing, including lab studies and clinical trials, to evaluate its effectiveness in real-world situations.
Introduction: Prostate cancer has emerged as a widespread health concern, with systemic inflammation believed to substantially contribute to its development and progression. The presence of systemic inflammatory responses has been established as an independent predictor of unfavorable long-term outcomes in prostate cancer patients. The goal of this study is to inhibit RXRα and RXRβ receptors, which are involved in prostate cancer, with Luteolin, Formononetin, and Kaempferol, with varying success.
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- Pancreatic ductal adenocarcinoma (PDAC) has a poor prognosis due to its aggressive nature and limited treatment options, prompting research into new therapeutic targets, particularly Liver X receptors (LXRα and LXRβ).
- Recent studies indicate that LXR ligands can inhibit cancer cell growth, with a focus on natural compounds like Baicalein, Beta-Sitosterol, and Polydatin for their potential effectiveness against PDAC.
- Findings suggest Baicalein has significant inhibitory effects on both LXR receptors, while Beta-Sitosterol is particularly strong against LXRβ, indicating a need for further research to understand their mechanisms and therapeutic potential.
Background/aim: Colorectal cancer (CRC) is a fatal malignancy type and its occurence still needs to be explored mechanistically. Notch, IL-1, and leptin crosstalk is reported to play a role in the proliferation, migration, and expression of proangiogenic molecules. In this study, we aimed to investigate the effect of inhibition of Notch, IL-1, and leptin on CRC.
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- * Triterpene compounds like soloxolone methyl (SM) show potential as anticancer agents, as they can induce apoptosis and inhibit tumor growth in breast cancer cells.
- * SM was effective in reducing cancer cell viability and inducing cell death through various mechanisms, including ROS production and ER stress, particularly against cancer stem cells.