Publications by authors named "E U Hale"

Transgender individuals commonly feel significant distress and discomfort, termed gender dysphoria, as a result of the discrepancy between their gender assigned at birth and their gender identity. A major source of gender dysphoria stems from distinct anatomical differences between the male and female chest. Gender-affirming mastectomy of transmasculine patients and breast augmentation for chest feminization of transfeminine patients, also referred to as top surgery, are often the first surgical interventions and most commonly pursued physical modifications for the treatment of gender dysphoria among this patient population.

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Objective: Pilot a clinical model and study to learn more about how employment impacts health in children and young adults with intellectual and developmental disabilities.

Background: As young individuals transition into adulthood, milestones such as independent living and gainful employment become paramount. However, for those with intellectual and developmental disabilities (IDD), these milestones can diverge notably from those of typically developing peers.

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Article Synopsis
  • Polycystic Kidney and Hepatic Disease 1-Like 1 (PKHD1L1) is a gene linked to autosomal recessive deafness (DFNB124) and is essential for the proper functioning of sensory hair cells in the cochlea, which are crucial for hearing.
  • The study investigates PKHD1L1 expression in mice throughout various developmental stages and its role in hair-cell bundle structure, revealing that absence of this gene leads to issues with stereocilia starting at 6 weeks of age.
  • PKHD1L1-deficient mice exhibit progressive hearing loss with age and are more vulnerable to permanent damage from noise exposure, highlighting the gene's importance in maintaining auditory function during development and against environmental
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Digital medicine is already well established in respiratory medicine through remote monitoring digital devices which are used in the day-to-day care of patients with asthma, COPD and sleep disorders. Image recognition software, deployed in thoracic radiology for many applications including lung cancer screening, is another application of digital medicine. Used as clinical decision support, this software will soon become part of day-to-day practice once concerns regarding generalisability have been addressed.

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