The COVID-19 Resource Centre: an invaluable tool for primary care.

Background: In response to the COVID-19 pandemic, the Ontario-based Centre for Effective Practice (CEP) established the COVID-19 Resource Centre (CRC) in March 2020. This platform rapidly became a critical source of clinical and practice guidance for primary care providers, highlighting the importance of effective information synthesis during public health emergencies.

Description: The article discusses the development of the CRC, emphasizing the application of librarianship principles in navigating the challenges posed by the pandemic's information overload and the scarcity of evidence.

Mesenchymal-epithelial transition and AXL inhibitor TP-0903 sensitise triple-negative breast cancer cells to the antimalarial compound, artesunate.

Triple-negative breast cancer (TNBC) is a difficult-to-treat, aggressive cancer type. TNBC is often associated with the cellular program of epithelial-mesenchymal transition (EMT) that confers drug resistance and metastasis. EMT and reverse mesenchymal-epithelial transition (MET) programs are regulated by several signaling pathways which converge on a group of transcription factors, EMT- TFs.

EMT/MET plasticity in cancer and Go-or-Grow decisions in quiescence: the two sides of the same coin?

Epithelial mesenchymal transition (EMT) and mesenchymal epithelial transition (MET) are genetic determinants of cellular plasticity. These programs operate in physiological (embryonic development, wound healing) and pathological (organ fibrosis, cancer) conditions. In cancer, EMT and MET interfere with various signalling pathways at different levels.

Zeb1-mediated autophagy enhances resistance of breast cancer cells to genotoxic drugs.

Autophagy is a highly conserved process of cellular self-digestion that involves the formation of autophagosomes for the delivery of intracellular components and dysfunctional organelles to lysosomes. This process is induced by different signals including starvation, mitochondrial dysfunction, and DNA damage. The molecular link between autophagy and DNA damage is not well understood yet.

AXL Receptor in Cancer Metastasis and Drug Resistance: When Normal Functions Go Askew.

The TAM proteins TYRO3, AXL, and MER are receptor tyrosine kinases implicated in the clearance of apoptotic debris and negative regulation of innate immune responses. AXL contributes to immunosuppression by terminating the Toll-like receptor signaling in dendritic cells, and suppressing natural killer cell activity. In recent years, AXL has been intensively studied in the context of cancer.