Publications by authors named "E Tukenmez Tigen"
Article Synopsis
- This study analyzed 331 patients with primary brain abscesses (PBAs) from 39 centers in 16 countries, focusing on infection causes, risk factors, and mortality outcomes over a 12-year period.
- Study results showed that the majority of patients were middle-aged men (average age 46.8), with symptoms like headaches and fever; Gram-positive cocci were the most common pathogens.
- Key factors influencing mortality at 42 days included intravenous drug use and malignancy, while factors affecting 180-day mortality included temporal lobe involvement and the presence of unidentified bacteria.
We report a rare case of nocardiosis with increased F-18 Fludeoxyglucose (F-18 FDG) uptake in widespread abscess foci of infection in an immunocompromised patient on positron emission tomography computed tomography (PET/CT) imaging. A relatively infrequent cause of nocardiosis, . is an opportunistic infection that may present with clinically aggressive disseminated disease.
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- Cefiderocol is effective against carbapenem-resistant bacteria, but its susceptibility varies based on different interpretive criteria from EUCAST and CLSI.
- Researchers tested 254 CRK blood isolates and found significant differences in resistance rates to cefiderocol when applying EUCAST versus CLSI criteria.
- High cefiderocol resistance rates were especially noted among NDM producers using EUCAST guidelines, leading to the recommendation that these criteria should be prioritized for testing until more clinical data is available.
Article Synopsis
- The study investigates the clinicopathological characteristics and mortality predictors in patients with peritoneal tuberculosis (TBP) using data from 38 medical centers across 13 countries.
- A total of 208 TBP patients were analyzed, with common comorbid conditions including HIV, diabetes, and chronic renal failure; 34 (16.3%) of these patients died from TBP.
- Key mortality risk factors identified include HIV positivity, cirrhosis, advanced age, and specific symptoms, leading to the development of a pioneering mortality predicting model to identify high-risk patients.
Article Synopsis
- Aminoglycosides are important for treating infections caused by carbapenemase-producing bacteria (CPK), but resistance to these antibiotics is rising, primarily due to 16S rRNA methyltransferases (RMTs) often found alongside NDM genes.
- In a study of 181 invasive CPK isolates, 60% were resistant to amikacin, gentamicin, and tobramycin, with most of the resistant isolates carrying RMTs, particularly ArmA and RmtC.
- The study found that the resistance is largely linked to specific clonal types, particularly ST2096 and ST14, which are associated with certain carbapenemases and other resistance genes, suggesting that clonal spread is a