Publications by authors named "E Tse"
Background: Point-of-care hepatitis C virus (HCV) testing streamlines testing and treatment pathways. In this study, we established an HCV model of care in a homelessness service by offering antibody and RNA point-of-care testing.
Methods: A nurse and peer-led HCV model of care with peer support were implemented between November 2021 and April 2022 at a homelessness service in Adelaide, Australia.
RA-0003022 () was identified as a high-quality covalent chemical probe for nsP2 cysteine protease (nsP2pro). Isoxazole covalently captured the active site C478 and inactivated the enzyme with a / ratio of 6000 Ms. A negative control analog RA-0025453 () retained the covalent warhead but demonstrated >100-fold decrease in enzyme inhibition.
View Article and Find Full Text PDFArticle Synopsis
- A study surveyed the general population in Hong Kong to assess their willingness to use teleconsultation in primary care, identifying factors influencing their decisions and the medical issues for which they would consider it.
- About 51.6% of respondents were open to using teleconsultation, with major motivations being belief in its effectiveness for health issues, government subsidies, and access to technology, while low education levels posed a significant barrier.
- The findings suggest the need for healthcare providers and the government to address these motivations and barriers, as well as to correct misconceptions, to promote teleconsultation in Hong Kong's primary care system.
The 5-year outcomes of a health-empowerment program on low-income children's behaviors and quality of life.
Child Adolesc Psychiatry Ment Health
November 2024
Background: This study aims to evaluate the 5-year impact of a Health Empowerment Program (HEP) on mitigating problematic conducts and enhancing the health-related quality of life (HRQOL) among children living in poverty.
Methods: A prospective cohort study (N = 239, Intervention group: n = 124, Comparison group: n = 115) was established with participants recruited between July 2013 and March 2016 and followed until November 2021. During the 5-year study period, children and their parents from the intervention group were invited to join a multi-dimensional HEP.
Multiple system atrophy (MSA) is a progressive neurodegenerative disease characterized by accumulation of α-synuclein cross-β amyloid filaments in the brain. Previous structural studies of these filaments by cryo-electron microscopy (cryo-EM) revealed three discrete folds distinct from α-synuclein filaments associated with other neurodegenerative diseases. Here, we use cryo-EM to identify a novel, low-populated MSA filament subtype (designated Type I) in addition to a predominant class comprising MSA Type II filaments.
View Article and Find Full Text PDF