Chitosan hydrogel with terbinafine--an evaluation of drug release.

The aim of this study was to evaluate rheological properties and release of terbinafine (an antifungal drug) from chitosan hydrogels, and test some additives as possible solvents, preservatives and potential chemical penetration enhancers. The release of terbinafine was better from hydrogel with glycerol (plastic flow), than that from hydrogel with propylene glycol (thixotropic flow), the presence of Tween 80 showed a negative influence on drug release from both types.

[Chitosan in topical preparations].

Chitosan in topical preparations Within the framework of experimental work at the Department of Pharmaceutical Technology of Slovak Medical University, "insect" chitin obtained from the buff-tailed bumblebee (Bombus terrestris) was processed to produce dosage forms and compared with commercially available chitin, or chitosan, obtained from shrimps (Pandalus borealus). The paper aimed to find whether insect chitin, or chitosan, possessed similar technological properties as commercially available and for topical preparations used products. Samples were prepared containing chitin, or chitosan, of different origin, 0.

[Drugs and preparations for the treatment of burns].

The paper summarizes drugs and preparations used and developed for the treatment of skin burns and presents the modes of defect treatment from the aspect of preventing microbial contamination, contact regulation with the external environment (breathing, humidity exchange, thermoregulation), healing, and formation of a new functional tissue. Its attention is focused on various types of substitutes of the damaged or absent skin - autografts, allografts, xenografts, and synthetic dressings as well as combined preparations.