Publications by authors named "E Toska"
Supraphysiological androgen (SPA) treatment can paradoxically restrict growth of castration-resistant prostate cancer with high androgen receptor (AR) activity, which is the basis for use of Bipolar Androgen Therapy (BAT) for patients with this disease. While androgens are widely appreciated to enhance anabolic metabolism, how SPA-mediated metabolic changes alter prostate cancer progression and therapy response is unknown. Here, we report that SPA markedly increased intracellular and secreted polyamines in prostate cancer models.
View Article and Find Full Text PDFSeborrheic dermatitis (SD), a chronic inflammatory skin condition consisting of itchy, red patches with greasy scales, has been linked to numerous systemic conditions. This review evaluates comorbidities and lifestyle factors that are associated with seborrheic dermatitis. A literary search was conducted in August 2024 using EMBASE, PubMed, and Medline Industries, and evaluated according to Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines.
View Article and Find Full Text PDFHead-to-head comparison of DaVinci and Hugo™ RAS robotic platforms for robot-assisted radical prostatectomy: a systematic review and meta-analysis of comparative studies.
Prostate Cancer Prostatic Dis
October 2024
Article Synopsis
- A systematic review and meta-analysis examined intra- and postoperative outcomes for robot-assisted radical prostatectomy (RARP) comparing DaVinci (DV-RARP) and Hugo™RAS (H-RARP) platforms.
- The study included eight research articles with over 1,100 patients, revealing no significant differences in operative time, blood loss, or postoperative outcomes between the two surgical methods.
- The only notable difference was longer docking time for H-RARP, and a lower node yield compared to DV-RARP, indicating a need for further evaluation on the effectiveness and biases in the existing studies.
Article Synopsis
- - This study investigates the impact of social protection, specifically government cash transfers and food security, on the health and well-being of adolescents living with HIV (ALHIV) in South Africa, focusing on achieving Global AIDS Targets like ART adherence, viral suppression, and reduced stigma.
- - Over four years, researchers collected data from 1,046 ALHIV, examining factors such as ART adherence, sexual behavior, and stigma, while using advanced regression models to analyze outcomes related to cash transfers and food security.
- - Results showed that receiving cash transfers and having food security were linked to better ART adherence and viral suppression, delayed sexual debut or consistent condom use, and lower enacted stigma among ALHIV, highlighting the importance of social support in
Purpose: Adolescent mothers face heightened economic and social vulnerabilities, which can place them at increased risk of intimate partner violence (IPV), prepandemic, and during COVID-19. However, few studies examine this population, and even less disaggregate findings by HIV status.
Methods: We analyzed data from 834 South African adolescent mothers, 35% living with HIV (LHIV), who reported on physical, psychological, and sexual IPV exposure at two interviews: 2018-2019 (prepandemic) and 2021-2022 (during COVID-19).