Altered metabolism of copper, zinc, and magnesium is associated with increased levels of glycated hemoglobin in patients with diabetes mellitus.

Diabetes mellitus (DM) is associated with the alterations in the metabolism of copper (Cu), zinc (Zn), and magnesium (Mg). The aim of the present study was to investigate plasma levels of these elements in patients with DM and in healthy subjects. Association between glycated hemoglobin and levels of metals was also evaluated.

[Bone turnover and bone density in type 1 diabetics in the initial stages of diabetic nephropathy].

Objective: To compare the bone turnover and bone mineral density in type 1 diabetic patients with normoalbuminuria and type 1 diabetic patients with diabetic nephropathy with microalbuminuria or mild proteinuria.

Methods: We studied 18 type 1 diabetic patients (Group A) with normoalbuminuria (UAE < 10 micrograms/min) and 8 type 1 diabetic patients (Group B) with UAE 100-1000 micrograms/min and serum creatinine below 150 mumol/l. Markers of bone formation (bone alkaline phosphatase--ALP-B, serum osteocalcin) and bone resorption (serum tartrate-resistant acid phosphatase--ACP-TR, urinary hydroxyproline) were determined.

[Diurnal changes in blood pressure, albuminuria and urinary excretion of retinol-binding protein in type I diabetics].

We studied 24-h ambulatory systolic and diastolic blood pressure (SBP, DBP), 16-h daytime and 8-h nighttime urinary excretion of albumin (UAE) and retinol-binding protein (URBP) in 20 type 1 diabetic patients (group 1) with normoalbuminuria (UAE < 20 micrograms/min) and 20 type 1 diabetic patients (group 2) with microalbuminuria and low proteinuria (UAE 20-500 micrograms/min). The groups were comparable in age, diabetes duration and actual glycaemic control. Daytime and nighttime SBP and DBP were higher in group 2 compared to group 1 (p < 0.

24-h ambulatory blood pressure, daytime and nighttime urinary albumin and retinol-binding protein excretion in type I diabetic patients.

We studied 24-h ambulatory blood pressure (SBP, DBP), actual glycemic control assessed from seven blood glucose measurements, 16-h daytime and 8-h nighttime urinary excretion of albumin (UAE) and retinol-binding protein (URBP) in 20 normoalbuminuric (group A, nighttime UAE < 20 micrograms/min) and 20 microalbuminuric and low-proteinuric type I diabetic patients (group B, nighttime UAE 20-500 micrograms/min) matched for age and diabetes duration. Glycemic control was similar in the two groups. Daytime and nighttime SBP and DBP were higher in group B compared to group A (p < 0.