Thyroid function and ioduria in infants after cardiac surgery: comparison of patients with primary and delayed sternal closure.

Objectives: Thyroid hormone alterations after cardiac surgery may be aggravated by the use of iodine antiseptics. We evaluated thyroid function and ioduria in infants with delayed sternal closure (DSC) who are exposed to povidone-iodine for sternal wound protection and compared them with findings in infants after primary sternal closure.

Design: Prospective clinical study.

IA-2A positivity rate at manifestation of type 1 diabetes mellitus in Slovak children culminates in September.

Background: New cases of type 1 diabetes mellitus (DM1) in Slovak children accumulate in late summer, autumn and winter.

Hypotheses: Children manifesting the disease in these seasons have higher autoantibody positivity than those first diagnosed in spring or summer.

Patients And Methods: One hundred and fifty Slovak children (and adolescents), aged 1-14 (15-17) years at the manifestation of DM1, born 1978-2000, with the disease manifested 1989-2001, were investigated at diagnosis by IA-2A, GADA and IAA autoantibody positivity, using standard radioimmunoassay procedures.

Thyroid hormone status after cardiac surgery in infants with delayed sternal closure and continued use of cutaneous povidone-iodine.

Objective: The aim of this prospective study was to examine whether providone-iodine used for sternal wound protection in infants with delayed sternal closure (DSC) influences the thyroid function.

Patients And Methods: Thyroid hormones (see bellow) and thyroxine binding globulin (TBG) were estimated by radioimmunoassay and ioduria by mass spectrometry in 20 infants in whom cutaneous povidone-iodine was continuously applied on the skin for 1-7 days before DSC after open heart surgery.

Results: In the early postoperative period the median levels of total triiodothyronine (TT3), total thyroxine (TT4) and thyroxine-binding globulin (TBG) were below the lower limit of normal, while these of reverse triiodothyronine (rT3) were above normal.

Thyroid hormone metabolism in pediatric cardiac patients treated by continuous povidone-iodine irrigation for deep sternal wound infection.

Objective: The purpose of this study was to assess the influence of povidone-iodine mediastinal irrigation used for the treatment of deep sternal wound infection (DSWI) on thyroid function.

Methods: Thyroid function was studied in 18 pediatric cardiac patients treated with continuous povidone-iodine irrigation for DSWI. The median age of patients was 8 months (18 days-5.

[Microalbuminuria and tubular reabsorption of minerals in children with type 1 diabetes mellitus].

Background: The most severe late complication of microangiopathic changes in diabetes mellitus type I (IDDM) is the diabetic nephropathy. The fully developed picture of diabetic nephropathy usually does not occur in children, however, original signs of altered renal functions may be present already.

Objectives: The study is aimed firstly at the detection of microalbuminuria and the relation between the amount of albumin urinary excretion and individual clinical indices such as age, degree of metabolic compensation, blood pressure.