Neurological findings in patients with pseudopapilloedema with and without verified optic disc drusen.

As part of a clinical examination of 200 patients with pseudopapilloedema with and without verified optic disc drusen, neuroophthalmological examinations were performed in 158, neurological examinations in 117 and electroencephalography in 109 patients. Headache and suspected papilloedema were the most frequent reasons for referral. Headache was one of the complaints in 102 patients.

Clinical and neurophysiological findings in heterozygotes for nonketotic hyperglycinemia.

Heterozygotes for nonketotic hyperglycinemia (NKH), a disorder of glycine degradation, have a slightly abnormal metabolism of glycine. As the severe neurological symptoms which are characteristic for the homozygotes are at least partially due to a disturbance of glycine function as a neurotransmitter, minor neuronal dysfunctions might be expected also in heterozygotes. Although their general health was within normal limits in these 13 heterozygotes, slight neurological symptoms and signs were observed.