Publications by authors named "E Tobias"
Article Synopsis
- The study evaluated the effects of the efavirenz, emtricitabine, and tenofovir disoproxil fumarate (EFV/FTC/TDF) treatment on metabolic, mitochondrial, and inflammatory parameters in people with HIV compared to untreated individuals.
- Results showed that while treatment significantly improved viral outcomes, it also led to increased levels of glucose, cholesterol, and triglycerides, indicating metabolic changes.
- Despite these metabolic alterations, mitochondrial function was mostly preserved, with some recovery in mitochondrial DNA, and a reduction in inflammatory markers was observed following treatment, suggesting some overall benefit.
Background: Aerobic capacity has shown to predict physical and mental health-related quality of life in bipolar disorder (BD). However, the correlation between exercise respiratory capacity and mitochondrial function remains understudied. We aimed to assess longitudinally intra-individual differences in these factors during mood episodes and remission in BD.
View Article and Find Full Text PDFPurpose: Disorders/differences of sex development (DSD) result from variants in many different human genes but, frequently, have no detectable molecular cause.
Methods: Detailed clinical and genetic phenotyping was conducted on a family with three children. A Sec31a animal model and functional studies were used to investigate the significance of the findings.
Article Synopsis
- - The study investigates mitochondrial function in patients with bipolar disorder (BD) during mood episodes and after clinical remission, focusing on the differences in mitochondrial respiration between these states and healthy controls.
- - Researchers observed a significant increase in mitochondrial oxygen consumption capacity (specifically electron transport chain activity) in BD patients during remission compared to acute episodes, suggesting improvements in mitochondrial bioenergetics.
- - The study involved 20 BD patients (15 manic and 5 depressive) and 10 healthy controls, highlighting that while the results showed trends of improvement in both mood episodes, the differences were more pronounced in clinical remission.