Publications by authors named "E Thiering"
Article Synopsis
- Chronic obstructive pulmonary disease (COPD) can be influenced by genetic factors and may stem from reduced lung growth during childhood, leading to lower lung function throughout life.
- A polygenic risk score (PRS) was calculated using data from a large genome-wide association study and tested for its correlation with lung function in individuals aged 4-50 from multiple research cohorts.
- Results indicated that higher PRS scores were associated with significantly lower lung function, measured by key indicators, starting from childhood and continuing into adulthood, regardless of smoking, sex, or asthma diagnosis.
Article Synopsis
- - This study explores how growth patterns during puberty relate to future health outcomes by analyzing height data from about 56,000 individuals across various ancestries using a technique called SITAR.
- - The researchers identified 26 significant genetic loci linked to height growth during puberty and found that different growth rates are associated with various health risks, like type 2 diabetes and heart conditions.
- - The findings suggest that there are multiple growth trajectories during puberty, each influencing adult health differently, indicating that no single growth pattern is the "best" for lifelong health outcomes.
Accelerometry-assessed sleep clusters and cardiometabolic risk factors in adolescents.
Obesity (Silver Spring)
January 2024
Objective: This study aimed to identify sleep clusters based on objective multidimensional sleep characteristics and test their associations with adolescent cardiometabolic health.
Methods: The authors included 1090 participants aged 14.3 to 16.
Atopic dermatitis (AD) is a common inflammatory skin condition and prior genome-wide association studies (GWAS) have identified 71 associated loci. In the current study we conducted the largest AD GWAS to date (discovery N = 1,086,394, replication N = 3,604,027), combining previously reported cohorts with additional available data. We identified 81 loci (29 novel) in the European-only analysis (which all replicated in a separate European analysis) and 10 additional loci in the multi-ancestry analysis (3 novel).
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