Publications by authors named "E Takakuwa"
The development of next-generation sequencing (NGS) has enabled the discovery of cancer-specific driver gene alternations, making precision medicine possible. However, accurate genetic testing requires a sufficient amount of tumor cells in the specimen. The evaluation of tumor content ratio (TCR) from hematoxylin and eosin (H&E)-stained images has been found to vary between pathologists, making it an important challenge to obtain an accurate TCR.
View Article and Find Full Text PDFBackground: Peripheral pulmonary stenosis (PPS) is a condition characterized by the narrowing of the pulmonary arteries, which impairs blood flow to the lung. The mechanisms underlying PPS pathogenesis remain unclear. Thus, the aim of this study was to investigate the genetic background of patients with severe PPS to elucidate the pathogenesis of this condition.
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- The study focuses on a 69-year-old man with chronic diabetic cystoid macular edema (CME) who underwent a surgical procedure (vitrectomy) to remove a specific cystoid lesion that was causing vision issues.
- Histopathological and immunohistochemical analyses were conducted on the removed lesion to examine its composition, revealing it contained fibrin and advanced glycation end-products (AGEs).
- This case report is notable as it provides the first detailed examination of the components found in refractory CME, suggesting that the presence of AGEs may hinder the degradation of fibrin, potentially contributing to the persistence of CME.
Article Synopsis
- Blastic plasmacytoid dendritic cell neoplasm (BPDCN) is a rare cancer that originates from certain immune cell precursors, but its diagnostic criteria are not well-defined.
- A review of case reports shows that most BPDCN diagnoses rely solely on three common markers (CD4, CD56, CD123), which can also be present in acute myeloid leukemia/myeloid sarcoma (AML/MS), making diagnosis challenging.
- The study proposes a new diagnostic criterion including TCF4, CD123, TCL1, and lysozyme due to limitations found in existing criteria and identifies that some cases previously diagnosed as BPDCN may actually be non-BPDCN, emphasizing the need for more
Article Synopsis
- Cryoglobulins are proteins that can solidify when exposed to cold temperatures, and Type I cryoglobulinemic vasculitis is linked to blood cancers.
- This report details a 47-year-old woman with steroid-resistant Type I cryoglobulinemic vasculitis associated with a condition called monoclonal gammopathy of undetermined significance (MGUS).
- Treatment with bortezomib and dexamethasone was effective, leading to a quick reduction in cryoglobulin levels and symptom improvement, highlighting the importance of addressing underlying conditions in severe cases.