Histological and stereological insights into renal and adrenal changes in pregnant rats exposed to wood smoke-derived PM2.5.

Air pollution, particularly fine particulate matter (PM2.5), is a global health issue affecting millions. In southern Chile, firewood used for heating exacerbates pollution, especially in winter.

Epithelial-Mesenchymal Transition Induced by a Metal Mixture in Liver Cells With Antioxidant Barrier Decreased.

Occupational exposure to arsenic (As), cadmium (Cd), and lead (Pb) affects many sectors, necessitating research to understand their transformation mechanisms. In this study, we characterized the process of epithelial-mesenchymal transition (EMT) in a rat hepatic epithelial cell line with decreased expression of catalase and glutamate cysteine ligase catalytic (GCLC) subunit that was exposed to a mixture of As, Cd, and Pb at equimolar occupational exposure concentrations. We evaluated the expression of genes and proteins involved in EMT.

Development of a Model for Predicting Mortality Among Patients Hospitalized with COVID-19 During Their Stay in a Clinical Centre.

Various tools have been proposed for predicting mortality among patients hospitalized with COVID-19 to improve clinical decision-making, the predictive capacities of which vary in different populations. The objective of this study was to develop a model for predicting mortality among patients hospitalized with COVID-19 during their time in a clinical centre. This was a retrospective study that included 201 patients hospitalized with COVID-19.

Expression profile of Bcl-2 family proteins in newly diagnosed multiple myeloma patients.

Antiapoptotic Bcl-2 family proteins are involved in myeloma cell survival. To date, their expression in multiple myeloma (MM) patients has mostly been analyzed at the RNA level. In the present study, we quantified for the first time the protein expression of the Bcl2-family members using a capillary electrophoresis immunoassay in 120 newly diagnosed MM patients, aged ≤65 years, treated in the context of the PETHEMA/GEM2012 study.

Factors impacting sleep center no-show rates post hospital discharge utilizing geospatial coding in Appalachia.

Study Objectives: Screening for early detection of sleep-disordered breathing (SDB) in hospitalized patients has been shown to reduce readmission rates. However, post-discharge polysomnography for confirmation of diagnosis is required. We analyzed factors for "no-shows" using geospatial techniques.