Investigation of selection signatures of dairy goats using whole-genome sequencing data.

Dairy goats, a livestock species with a long history of milk production, are essential for the economic advancement of nations, particularly in regions experiencing growth. In this study, we gathered whole-genome resequencing data of 58 goats, including 34 dairy goats and 24 wild goats (Bezoar), to explore the selection signatures linked to milk production traits using ROH (Runs of homozygosity), CLR (composite likelihood ratio), Fst (Fixation index), XP-EHH (Ex-tended haplotype homozygosity across populations) and XP-CLR(Cross-population composite likelihood ratio test) methods. Analysis of five tests of selection signatures for dairy goats revealed a total of 210 genes, with 24 genes consistently identified in at least two approaches.

Pharmacokinetics, tolerability, and safety of TBI-223, a novel oxazolidinone, in healthy participants.

TBI-223 is an oxazolidinone antibiotic under clinical development for the treatment of tuberculosis. Preclinical data indicate potent antituberculosis activity and a potentially improved safety profile over linezolid. In a single-ascending dose study and a multiple-ascending dose study in 114 healthy adults, TBI-223 was generally safe and well tolerated at single doses up to 2,600 mg and multiple doses up to 2,400 mg daily over 14 days.

Antidepressants reactivate developmental plasticity through remodeling of extracellular matrix.

Selective serotonin reuptake inhibitors (SSRIs) are widely used to treat mood and anxiety disorders, yet their molecular mechanisms of action remain poorly understood. Here, we show that chronic treatment with the SSRI fluoxetine reinstates a developmental plasticity program in the dentate gyrus (DG) by remodeling the extracellular matrix (ECM). Fluoxetine elicited a robust transcriptomic response in the DG, where mature granule cells adopted a juvenile-like profile.

Evolutional, expressional and functional analysis of WRKY gene family reveals that PbeWRKY16 and PbeWRKY31 contribute to the Valsa canker resistance in Pyrus betulifolia.

The WRKY transcription factor family plays a crucial role in regulating plant growth and stress responses. However, there are few studies on the regulation of resistance to Valsa canker. In this study, a comprehensive analysis of WRKY genes across 19 plant species was conducted.