Developing Topics.

Background: Population-based cohort studies play a crucial role in unraveling the underlying causes of dementia among older individuals. While previous research has indicated an increase in limbic-predominant age-related TDP-43 encephalopathy neuropathological change (LATE-NC) with age, only limited investigations have delved into this phenomenon within a population-based context. In this study, we examined the prevalence of LATE-NC and its correlations with other brain pathologies and cognitive function in individuals aged > 85 years.

Limbic-predominant age-related TDP-43 encephalopathy in the oldest old: a population-based study.

Population-based cohort studies are essential for understanding the pathological basis of dementia in older populations. Previous studies have shown that limbic-predominant age-related TDP-43 encephalopathy neuropathologic change (LATE-NC) increases with age, but there have been only a few studies, which have investigated this entity in a population-based setting. Here we studied the frequency of LATE-NC and its associations with other brain pathologies and cognition in a population aged ≥ 85 years.

[Prognosis in gestosis].

Red cell osmotic and peroxide resistance characteristics were used in the diagnosis of preclinical forms of gestosis in pregnant women. These parameters reduced 2 and 1.2 times vs.

[Effect of maternal genotype characteristics on fetal adaptation to intra- and extrauterine conditions].

Effects of the maternal genotype on the fetal and neonatal compensatory-adaptive patterns have been examined in 1396 newborns. Correlations were found between the ante- and intrapartum progress, physical development of the newborns, early neonatal course and the maternal phenotype. Maternal-fetal compatibility was found to influence the neonatal status and later morbidity and mortality.